4 Answers
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Eve Online mmorpg about space
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A lot of visual novels are Made with Python
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the famous Angry Birds (in Python)
https://github.com/estevaofon/angry-birds-python
(does not work at SL, could try at your home computer)
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Civilization IV (and maybe others in the series, not sure) used Python for scripting events in custom scenarios. I'm pretty sure there are numerous examples out there of this sort, where the game engine and core internals are written in C but there are hooks that allow various aspects of the game to be modified with Python scripting.