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Tkinter part of Python <-- most common option
or
wxPython a wxWindows interface if you're familiar with wxWidgets
or
JPython if you're familiar with making GUI's in Java
or
PyQt if you're familiar with Qt
There are more frameworks, like Kivy for touch, but these seem to be the most used.
A couple of free basic tutorials to get you started:
https://www.tutorialspoint.com/python/python_gui_programming.htm
http://www.python-course.eu/python_tkinter.php